Terminology Service for NFDI4Health

Oncogene Activation Process

Go to external page http://purl.obolibrary.org/obo/NCIT_C18909


Any DNA sequence alteration process occurring in a proto-oncogene, resulting in loss of regulation of the gene product, and predisposing the cell to neoplastic transformation. Proto-oncogenes are ordinarilly involved in transduction of signals that regulate cell growth and differentiation. Activation of such genes overrides the normal mechanisms of regulation and is an important step in the process of cellular transformation. [ ]

Term info

Label

Oncogene Activation Process

Synonyms
  • Oncogene Activation
  • Oncogene Activation Process
DesignNote

Gain of function mutations in proto-oncogenes generally act in a dominant fashion, meaning that only a single copy of the DNA sequence alteration is necessary for the step along the path to transformation.

Legacy Concept Name

Oncogene_Activation

Preferred Name

Oncogene Activation Process

Semantic Type

Cell or Molecular Dysfunction

UMLS CUI

C1518575

code

C18909