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T-Cell Differentiation

Go to external page http://purl.obolibrary.org/obo/NCIT_C19055

Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction. Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells. (NCI/OSP) [ ]

Term info

Label

T-Cell Differentiation

Synonyms
  • T-Cell Development
  • T-Cell Differentiation
  • T-Cell Ontogeny
  • T-Lymphocyte Development
Legacy Concept Name

T-Cell_Development

Preferred Name

T-Cell Differentiation

Semantic Type

Cell Function

UMLS CUI

C1155013

code

C19055