Terminology Service for NFDI4Health
T-Cell Receptor Activation
Go to external page
http://purl.obolibrary.org/obo/NCIT_C19060
Any process in which a specific pair of interactions is observed between a T cell and an antigen-presenting cell, where the interactions include those between the T cell receptor and the major histocompatibility complex and those between CD28 and B7 family members. This process is involved in anergy and specification of the immune response to a particular antigen. [ ]
Term info
Label
T-Cell Receptor Activation
Synonyms
- T-Cell Receptor Activation
- T-Cell Receptor Interaction
- TCR Activation
- TCR Interaction
DesignNote
TCR Activation during T cell development and proliferation involves binding to specific antigen by Ig-like heterodimeric transmembrane surface alpha/beta (antigen/MHC) or gamma/delta (antigen) glycoprotein receptors non-covalently associated with CD3 complex on T lymphocytes. Antigen-bound TCRs activate MAPKs and JNK1 through CD3 antigens, adaptor protein LAT, and tyrosine kinases LCK and ZAP70.
Legacy Concept Name
TCR_Activation
Preferred Name
T-Cell Receptor Activation
Semantic Type
Molecular Function
UMLS CUI
C1515144
code
C19060