G(i) Alpha
Human G(i) Alpha Proteins (G-Alpha 1 Family) are 40-kDa guanine nucleotide-binding alpha protein subunits of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase and regulate other plasma membrane enzymes are substrates for pertussis toxin. (NCI) [ ]
Term info
G(i) Alpha
- Adenylate Cyclase-Inhibiting G Alpha Protein
- G Protein Alpha Inhibiting Polypeptide
- G(i) Alpha
- G(i) Alpha Protein
G-i_Alpha
G(i) Alpha
Amino Acid, Peptide, or Protein
C1333649
C19275
Term relations
- Protein Family
- Gene_Product_Plays_Role_In_Biological_Process some Signal Transduction
- Gene_Product_Has_Biochemical_Function some Heterotrimeric G Protein Subunit
- Gene_Product_Is_Physical_Part_Of some Heterotrimeric G Protein
- Gene_Product_Plays_Role_In_Biological_Process some Protein-Protein Interaction