Terminology Service for NFDI4Health

TNF Receptor Family Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C19285


Members of the tumor necrosis factor receptor (TNFR) family play a key role in regulating the immune response to infection. They are cell-surface proteins that interact with a corresponding TNF-related ligand family. The receptors share homology in the extracellular domain, which contains 3 to 6 cysteine-rich pseudorepeats, but are generally not related in their cytoplasmic regions. However, the intracellular domains (ICDs) of TNFR family members TNFR1 and FAS/APO1/CD95, which can activate apoptotic cell death, do have a region of homology in an oligomerization interface known as the death domain. (from OMIM 603366) [ ]

Term info

Label

TNF Receptor Family Protein

Synonyms
  • TNF Receptor
  • TNF Receptor Family Protein
  • TNF Receptor Superfamily
  • TNFR
  • TNFRSF Protein
  • Tumor Necrosis Factor Receptor
  • Tumor Necrosis Factor Receptor Family
  • Tumor Necrosis Factor Receptor Superfamily
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

Display Name

TNF Receptor Family Protein

Legacy Concept Name

TNF_Receptor_Family_Protein

Preferred Name

TNF Receptor Family Protein

Semantic Type

Amino Acid, Peptide, or Protein, Receptor

UMLS CUI

C0077503

code

C19285