Terminology Service for NFDI4Health
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Ubiquitination

Go to external page http://purl.obolibrary.org/obo/NCIT_C19358

Ubiquitin is a family of widely distributed proteins found in all eukaryotes that contain a highly conserved sequence of 76 amino acids identical in organisms from humans to insects. It participates in diverse cellular functions by conjugation to other proteins through its carboxy terminus. Ubiquitination is associated with many highly regulated biological events including protein degradation, chromatin remodelling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Newly discovered families of ubiquitination and deubiquitination enzymes participate in these processes. Ubiquitination enzymes may provide new therapeutic targets and ways of intervention in many human diseases. [ ]

Term info

Label

Ubiquitination

Synonyms
  • Protein Ubiquitination
  • Ubiquitilation
  • Ubiquitination
  • Ubiquitinoylation
  • Ubiquitylation
Legacy Concept Name

Ubiquitination

Preferred Name

Ubiquitination

Semantic Type

Molecular Function

UMLS CUI

C1519751

code

C19358

Term relations

Related from:
Gene_Plays_Role_In_Process