Terminology Service for NFDI4Health
Signal Transducer and Activator of Transcription
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http://purl.obolibrary.org/obo/NCIT_C19618
A family of cytoplasmic proteins that are activated by phosphorylation in response to a large number of cytokines, growth factors, and hormones. They dimerize and translocate to the nucleus upon activation, where they bind to regulatory cis-elements of specific target genes. [ ]
Term info
Label
Signal Transducer and Activator of Transcription
Synonyms
- STAT
- STAT Protein
- Signal Transducer and Activator of Transcription
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
Display Name
Signal Transducer and Activator of Transcription
Legacy Concept Name
Signal_Transducer_and_Activator_of_Transcription
Preferred Name
Signal Transducer and Activator of Transcription
Semantic Type
Amino Acid, Peptide, or Protein
UMLS CUI
C1366753
code
C19618
Term relations
Subclass of:
- Protein Family
- Gene_Product_Has_Biochemical_Function some Transcription Factor
- Gene_Product_Plays_Role_In_Biological_Process some Signal Transduction
- Gene_Product_Plays_Role_In_Biological_Process some Transcriptional Regulation
- Gene_Product_Has_Biochemical_Function some Signaling Protein
- Gene_Product_Encoded_By_Gene some Signal Transducer and Activator of Transcription Family Gene