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Mediator Complex

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A protein complex that is involved in the initiation of transcription. This complex is composed of over 30 protein subunits, which binds to the RNA polymerase II holoenzyme complex and facilitates the interaction of transcription factors with the polymerase. [ ]

Term info

Label

Mediator Complex

Synonyms
  • Mediator
  • Mediator Coactivator
  • Mediator Coactivator Complex
  • Mediator Complex
  • Mediator of Activation
  • Mediator of RNA Polymerase II Transcription
DesignNote

The human Mediator complex is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. (UniProt)

Legacy Concept Name

Mediator_of_Activation

Preferred Name

Mediator Complex

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C1363844

code

C19864