Terminology Service for NFDI4Health
Gcn5p
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http://purl.obolibrary.org/obo/NCIT_C19894
Gcn5p is a transcriptional coactivator required for correct expression of various genes in yeast. Several transcriptional regulators, including Gcn5p, possess intrinsic histone acetyltransferase (HAT) activity in vitro. [ ]
Term info
Label
Gcn5p
Synonyms
- Gcn5p
DesignNote
Containing a bromodomain, Gcn5p is a general transcriptional activator operating in concert with other DNA-binding transcriptional activators, such as GCN4 or HAP2/3/4. Gcn5p functions in the SAGA adaptor/HAT complex as a nucleosomal histone acetyltransferase to promote transcriptional activation. HAT Gcn5p also functions as a heterodimer with ada2 as part of the ADA adaptor/HAT complex that consists of hfi1/ada1, ada2, ada3, spt20/ada5 and gcn5. It has a strong preference for Lysine 14 of H3 and a lower preference for Lysines 8, 16 of H4. (from SWISS-PROT Q03330, SGD S0003484, LocusLink 2648)
Legacy Concept Name
Gcn5p
Preferred Name
Gcn5p
Semantic Type
Amino Acid, Peptide, or Protein, Enzyme
UMLS CUI
C1171569
code
C19894