SKI Oncoprotein
The c-SKI proto-oncogene encodes a transcriptional repressor that homo- and heterodimerizes with the related protein, snoN. SMAD3 associates with nuclear SKI protein in response to TGFB1 signaling, repressing transcriptional activation by SMAD3, and rendering cells resistant to the growth-inhibitory effects of TGFB. The effects of SKI can be overcome by increased expression of SMAD3. (from OMIM 164780 and NCI) [ ]
Term info
SKI Oncoprotein
- SK Oncogene
- SKI Oncoprotein
SKI_Oncoprotein
SKI Oncoprotein
Amino Acid, Peptide, or Protein, Biologically Active Substance
C1335830
C19993