Initiation of transcription from eukaryotic protein-coding genes is a complex process requiring RNA polymerase II (Pol II) and a cadre of transcription factors. These factors can be divided into 2 classes on the basis of their function: the general factors that are required for transcription of all Pol II genes, and sequence-specific factors that are required for regulating expression. The general transcription factors and Pol II form a specific multiprotein complex near the transcription start site by interacting with core promoter elements. The most common core element is the TATA box, typically located 25-30 bp upstream of the transcriptional start site or initiator element. Sequence-specific transcription factors that bind to DNA-sequence elements located proximal and distal to the core promoter elements can dramatically enhance or repress transcription. (from OMIM 189962)

Transcription Factor

Transcription_Factor_Gene

Transcription Factor Gene

Gene or Genome

C0812327

C20420

• Transcription Factor
• AP-2 Family Transcription Factor