Terminology Service for NFDI4Health
JSON

Platelet-Derived Growth Factor

Go to external page http://purl.obolibrary.org/obo/NCIT_C20448

A family of growth factors that act as potent mitogens and are involved in the stimulation of angiogenesis. There are four members of this family (platelet-derived growth factor A, B, C and D) that are characterized by a core motif of eight cysteines. They bind to their cognate receptor tyrosine kinases (platelet-derived growth factor receptor family) as homodimers or heterodimers to stimulate signaling. [ ]

Term info

Label

Platelet-Derived Growth Factor

Synonyms
  • PDGF
  • PDGF Family
  • Platelet-Derived Growth Factor
  • Platelet-Derived Growth Factor Family
  • platelet-derived growth factor
ALT DEFINITION

A family of molecules released from platelets (tiny pieces of cells that are found in the blood and that help the blood clot). Forms of PDGF help to heal wounds and to repair damage to blood vessel walls. They also help blood vessels grow.

DesignNote

Vascular endothelial growth factors are considered a subfamily of the platelet-derived growth factor family.

Legacy Concept Name

Platelet-Derived_Growth_Factor

Preferred Name

Platelet-Derived Growth Factor

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C0032200

code

C20448