Terminology Service for NFDI4Health

Interleukin-12

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Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI) [ ]

Term info

Label

Interleukin-12

Synonyms
  • CLMF
  • Cytotoxic Lymphocyte Maturation Factor
  • IL-12
  • IL-12 p70
  • IL-12p70
  • IL12
  • Interleukin 12
  • Interleukin-12
  • NKSF
  • Natural Killer Cell Stimulatory Factor
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

Display Name

Interleukin-12

Legacy Concept Name

Interleukin-12

Preferred Name

Interleukin-12

Semantic Type

Amino Acid, Peptide, or Protein, Immunologic Factor

UMLS CUI

C0123759

code

C20514