Terminology Service for NFDI4Health

HMGA Family Gene

Go to external page http://purl.obolibrary.org/obo/NCIT_C20573


Human HMGA Family Genes encode HMGA proteins that participate in many nuclear processes ranging from chromosome and chromatin mechanics to transcription factors that regulate gene expression. Hence, they influence diverse biological processes including cell growth, proliferation, differentiation and death. HMGA proteins contain three AT-hooks that bind to minor groove AT-rich stretches. HMGA proto-oncogenes promote tumor progression and metastasis when overexpressed. High constitutive HMGA expression is consistently observed in cancers, with increasing concentrations being correlated with increasing malignancy. (NCI) [ ]

Term info

Label

HMGA Family Gene

Synonyms
  • HMGA Family Gene
  • High Mobility Group A Gene Family
Gene Encodes Product

HMGA Family Protein

Legacy Concept Name

HMGA_Family_Gene

Preferred Name

HMGA Family Gene

Semantic Type

Gene or Genome

UMLS CUI

C1333907

code

C20573