Terminology Service for NFDI4Health
Granzyme
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http://purl.obolibrary.org/obo/NCIT_C20619
A family of serine endopeptidases. Members of this family are stored in the granules of cytotoxic T cells. Upon release of the granules, these enzymes enter infected cells where they can proteolytically stimulate caspase activation and initiate apoptosis. [ ]
Term info
Label
Granzyme
Synonyms
- EC 3.4.21.-
- Granule-Secreted Enzyme
- Granzyme
- Granzymes
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
Display Name
Granzyme
Legacy Concept Name
Granzyme
Preferred Name
Granzyme
Semantic Type
Amino Acid, Peptide, or Protein, Enzyme
UMLS CUI
C1333877
code
C20619
Term relations
Subclass of:
- Protein Family
- Gene_Product_Has_Biochemical_Function some Serine Protease
- Gene_Product_Plays_Role_In_Biological_Process some Proteolysis
- Gene_Product_Encoded_By_Gene some Peptidase Gene
- Gene_Product_Plays_Role_In_Biological_Process some Cell-Mediated Immunity
- Gene_Product_Plays_Role_In_Biological_Process some Positive Regulation of Apoptosis