Terminology Service for NFDI4Health

TFIIH Subunit Gene

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For transcription initiation, the nonphosphorylated RNA polymerase II is recruited by TFIIF to the DB complex. This complex is recognized by TFIIE, TFIIH, and TFIIJ to form a transcription-competent complex. Phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II controls the transition from transcription initiation to elongation and TFIIH contains a kinase activity for phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. TFIIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase. TFIIH is a multisubunit factor of at least 5 proteins of 92, 62, 43, 40, and 35 kD. A 52-kD subunit has also been identified as a component of the TFIIH core, along with p89, p62, p44, and p34. (from OMIM, LocusLink and NCI) [ ]

Term info

Label

TFIIH Subunit Gene

Synonyms
  • TFIIH Subunit Gene
DesignNote

Human TFIIH Subunit Genes include CAK complex genes (CDK7, CCNH, and MAT1) and TFIIH Core Subunit Genes, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, ERCC2, and ERCC3.

Legacy Concept Name

TFIIH_Subunit_Gene

Preferred Name

TFIIH Subunit Gene

Semantic Type

Gene or Genome

UMLS CUI

C1336616

code

C20654