Ribonucleotide Reductase Subunit Gene
Ribonucleotide Reductase Subunit Genes (RRM1 and RRM2) encode the M1 Chain and M2 Chain subunits of Ribonucleoside-Diphosphate Reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate site and catalytic site regulate enzyme activity. Allosteric control by deoxynucleoside triphosphates and by ATP bound to M1 prevents DNA replication and cell proliferation. An M1 catalytic site only forms in the presence of M2. M2 synthesis is cell-cycle dependent. p53 regulates ribonucleotide reductase by interaction with p53R2 as well as the M2 subunit. (NCI) [ ]
Term info
Ribonucleotide Reductase Subunit Gene
- Ribonucleotide Reductase Subunit Gene
Ribonucleotide Reductase Subunit
Ribonucleotide_Reductase_Subunit_Gene
Ribonucleotide Reductase Subunit Gene
Gene or Genome
C1335784
C20847