Mesothelin
Mesothelin (630 aa, ~69 kDa) is encoded by the human MSLN gene. This protein may play a role in cellular adhesion. [ ]
Term info
Mesothelin
- CAK1 Antigen
- MSLN
- Mesothelin
- Pre-Pro-Megakaryocyte-Potentiating Factor
- mesothelin
NCIT_C116977, NCIT_C142800, NCIT_C142799
A protein found on the surface of certain types of normal cells and cancer cells. Mesothelin may help these cells stick together and send signals. A higher-than-normal amount of mesothelin is found on some cancer cells, including mesothelioma, pancreatic cancer, and ovarian cancer.
CTRP
An antibody that reacts with ovarian cancers and mesotheliomas was used to isolate a cell surface antigen named mesothelin. Although the function of mesothelin is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. Three transcript variants have been described for this gene and their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. The protein isoform named MPF is a cytokine with megakaryocyte potentiating activity. The soluble member encoded by the third splice variant is detected in ovarian carcinoma; the full length sequence of the third variant has not been described. (LocusLink)
Mesothelin
Mesothelin
Mesothelin
601051
Mesothelin
Amino Acid, Peptide, or Protein
Q13421
C1429990
C20887
Term relations
- MSLN Gene Product
- Gene_Product_Encoded_By_Gene some MSLN Gene
- Gene_Product_Has_Chemical_Classification some Glycoprotein
- Gene_Product_Is_Biomarker_Of some Malignant Ovarian Neoplasm
- Gene_Product_Expressed_In_Tissue some Lung
- Gene_Product_Has_Associated_Anatomy some Plasma Membrane
- Gene_Product_Is_Biomarker_Type some Tumor Marker