Terminology Service for NFDI4Health
Cadherin-3
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http://purl.obolibrary.org/obo/NCIT_C21020
Cadherin-3 (829 aa, ~91 kDa) is encoded by the human CDH3 gene. This protein is involved in calcium-dependent cell-cell adhesion. [ ]
Term info
Label
Cadherin-3
Synonyms
- CDH3
- Cadherin 3
- Cadherin-3
- P-Cadherin
- Placental Cadherin
- Placental Calcium-Dependent Adhesion Protein
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
DesignNote
Encoded by human CDH3 Gene (CDH Family), 829-amino acid 91 kD (precursor) Placental Cadherin is a homophilic Ca(2+)-dependent cell-cell adhesion type I membrane glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Aberrant expression is observed in cervical adenocarcinomas. Hypotrichosis with juvenile macular dystrophy is caused by production of a truncated protein resulting from a homozygous nucleotide deletion.
Display Name
Cadherin-3
Legacy Concept Name
P-Cadherin
OMIM Number
114021
Preferred Name
Cadherin-3
Semantic Type
Amino Acid, Peptide, or Protein
Swiss Prot
P22223
UMLS CUI
C0030128
code
C21020
Term relations
Equivalent to:
- Cadherin and Gene_Product_Is_Element_In_Pathway some Cell Adhesion Molecule Signaling Pathway and Gene_Product_Has_Chemical_Classification some Glycoprotein and Gene_Product_Has_Chemical_Classification some Transmembrane Protein and Gene_Product_Has_Organism_Source some Human and Gene_Product_Has_Associated_Anatomy some Plasma Membrane and Gene_Product_Expressed_In_Tissue some Placenta and Gene_Product_Has_Structural_Domain_Or_Motif some Transmembrane Domain and Gene_Product_Has_Structural_Domain_Or_Motif some Cytoplasmic Domain and Gene_Product_Has_Structural_Domain_Or_Motif some Cadherin Domain and Gene_Product_Plays_Role_In_Biological_Process some Cell Adhesion Process and Gene_Product_Encoded_By_Gene some CDH3 Gene