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Cadherin-5

Go to external page http://purl.obolibrary.org/obo/NCIT_C21021

Cadherin-5 (784 aa, ~88 kDa) is encoded by the human CDH5 gene. This protein is involved in endothelial cell polarity and cell-cell adhesion. [ ]

Term info

Label

Cadherin-5

Synonyms
  • 7B4 Antigen
  • CD144 Antigen
  • CDH5
  • Cadherin 5
  • Cadherin-5
  • Endothelial-Specific Cadherin
  • VE-Cadherin
  • Vascular Endothelial Cadherin
  • Vascular Endothelial Cadherin 1
DesignNote

Encoded by human CDH5 Gene (CDH Family), 784-amino acid 87.5 kD (precursor) Vascular Endothelial Cadherin is a Ca(2+)-dependent homophilic endothelial cell-cell adhesion type I membrane glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Expressed specifically in endothelial cells and brain, VE-Cadherin is found mainly at cell-cell boundaries, associated with intercellular junctions. CDH5 may play a role in endothelial cell cohesion and organization of intercellular junctions. CDH5/beta-catenin signaling may control endothelial survival. CDH5 associates with alpha-catenin, forming a link to the cytoskeleton.

Legacy Concept Name

VE-Cadherin

OMIM Number

601120

Preferred Name

Cadherin-5

Semantic Type

Amino Acid, Peptide, or Protein

Swiss Prot

P33151

UMLS CUI

C0300423

code

C21021