Terminology Service for NFDI4Health

TNF Receptor Family Gene

Go to external page http://purl.obolibrary.org/obo/NCIT_C21165


Human TNF Receptor Family Genes encode transmembrane receptor proteins regulated by TNF Family ligands. TNF receptors typically contain intracellular death domains involved in the formation of a signal transducing death-inducing complex that includes FADD and caspases that trigger an apoptotic caspase cascade. Some TNF receptors can activate NF-Kappa-B, MAPK3/ERK1, MAPK8/JNK, BIRC1, BIRC2, BAG4/SODD, TRADD, or TRAF2 and transduce inflammation or anti-apoptotic proliferating signals. Some TNF Family Receptors act as competitive decoy receptors in bone resorption or suppress FasL- and LIGHT-mediated cell death. (NCI) [ ]

Term info

Label

TNF Receptor Family Gene

Synonyms
  • TNF Receptor Family Gene
  • TNFRSF Gene
  • Tumor Necrosis Factor Receptor Family Gene
  • Tumor Necrosis Factor Receptor Superfamily Gene
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

Display Name

TNF Receptor Family Gene

Legacy Concept Name

TNF_Receptor_Family_Gene

Preferred Name

TNF Receptor Family Gene

Semantic Type

Gene or Genome

UMLS CUI

C1336652

code

C21165