Terminology Service for NFDI4Health
E3 Ubiquitin-Protein Transferase
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http://purl.obolibrary.org/obo/NCIT_C21254
An ATP-dependent aminoacyltransferase that catalyzes the third step in the ubiquitination reaction via the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to lysine residues found in the final substrate protein. [ ]
Term info
Label
E3 Ubiquitin-Protein Transferase
Synonyms
- E3 Ubiquitin Ligase
- E3 Ubiquitin Transferase
- E3 Ubiquitin-Protein Ligase
- E3 Ubiquitin-Protein Transferase
DesignNote
The IUBMB has recategorized E3 ubiquitin-protein ligases as transferases (EC 2). There are 2 categories of E3 enzymes based on the structure of the active site: HECT-type (EC 2.3.2.26) and RING-type (EC 2.3.2.27).
Legacy Concept Name
E3_Ubiquitin_Ligase
NCI META CUI
CL449066
Preferred Name
E3 Ubiquitin-Protein Transferase
Semantic Type
Amino Acid, Peptide, or Protein, Enzyme
code
C21254
Term relations
Subclass of:
- Acyltransferase
- Gene_Product_Is_Physical_Part_Of some Ubiquitin Protein Ligase
- Gene_Product_Encoded_By_Gene some Ubiquitin-Transferase Gene
- Gene_Product_Has_Biochemical_Function some Ubiquitination Regulation Protein
- Gene_Product_Plays_Role_In_Biological_Process some Ubiquitination
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