Terminology Service for NFDI4Health
Mesencephalic Astrocyte-Derived Neurotrophic Factor
Go to external page
http://purl.obolibrary.org/obo/NCIT_C21337
Mesencephalic astrocyte-derived neurotrophic factor (179 aa, ~20 kDa) is encoded by the human MANF gene. This protein is involved in both the function and survival of dopaminergic neurons. [ ]
Term info
Label
Mesencephalic Astrocyte-Derived Neurotrophic Factor
Synonyms
- ARMET
- ARMET Protein
- Arginine-Rich Mutated in Early Stage Tumors
- Arginine-Rich Protein
- Mesencephalic Astrocyte-Derived Neurotrophic Factor
- Protein ARMET
DesignNote
The product of the MANF gene was originally thought to have an arginine-rich sequence in the amino terminal region, however; this genetic information is in the 5'-untranslated region of the mRNA. The mutation that is involved in tumor formation occurs in the initiation codon of the gene (previously numbered as codon 50) and results from either deletion of the codon or a point mutation (AUG to AGG). (Entrez Gene and SwissProt)
Legacy Concept Name
ARMET_Protein
OMIM Number
601916
Preferred Name
Mesencephalic Astrocyte-Derived Neurotrophic Factor
Semantic Type
Amino Acid, Peptide, or Protein, Biologically Active Substance
Swiss Prot
P55145
UMLS CUI
C0390113
code
C21337