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Breast Cancer Anti-Estrogen Resistance 3 Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C21496

Breast cancer anti-estrogen resistance protein 3 (825 aa, ~93 kDa) is encoded by the human BCAR3 gene. This protein may be involved in receptor-mediated signaling. [ ]

Term info

Label

Breast Cancer Anti-Estrogen Resistance 3 Protein

Synonyms
  • BCAR3
  • Breast Cancer Anti-Estrogen Resistance 3
  • Breast Cancer Anti-Estrogen Resistance 3 Protein
  • Novel SH2-Containing Protein 2
  • SH2 Domain-Containing Protein 3B
DesignNote

Encoded by human BCAR3 Gene, the 92.6 kD 825-amino acid BCAR3 Protein contains a putative SH2 domain, a hallmark of tyrosine kinase signaling molecules, and sequences homologous to CDC48 (Yeast). Abundant expression is seen in heart, placenta, skeletal muscle, spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and several cancer cell lines, but not in nonmalignant breast tissue. NSP2 induces anti-estrogen resistance in estrogen-dependent breast tumors. (SWISS-PROT, OMIM)

Legacy Concept Name

Breast_Cancer_Anti-Estrogen_Resistance-3_Protein

OMIM Number

604704

Preferred Name

Breast Cancer Anti-Estrogen Resistance 3 Protein

Semantic Type

Amino Acid, Peptide, or Protein, Biologically Active Substance

Swiss Prot

O75815

UMLS CUI

C1309026

code

C21496