Terminology Service for NFDI4Health

Complement Component Gene

Go to external page http://purl.obolibrary.org/obo/NCIT_C21518


These genes encode more than 30 proteins of the complement system engaged in host defense. This system provides both an independent immune system capable of attacking microbes as well as other foreign material and an adjunct to the antibody system. Once activated, the complement system fires in a cascade-like fashion in which one component activates the next. Both swift and powerful, millions of complement components can deposit on an invading microbe within only a few minutes. Such a potent system requires strict regulation to avoid host injury. Membrane cofactor protein (MCP) is one critical regulator aimed at controlling inadvertent complement activation on host cells and nearly every cell examined expresses MCP on its cell membrane. [ http://research.medicine.wustl.edu ]

Term info

Label

Complement Component Gene

Synonyms
  • Complement Component Gene
Gene Encodes Product

Complement Component Protein

Legacy Concept Name

Complement_Component_Gene

Preferred Name

Complement Component Gene

Semantic Type

Gene or Genome

UMLS CUI

C1333135

code

C21518