Terminology Service for NFDI4Health
Dihydrofolate Reductase Inhibitor
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http://purl.obolibrary.org/obo/NCIT_C2153
Any substance that inhibits dihydrofolate reductase, an enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate, an essential reaction for de novo glycine and purine synthesis. Inhibition of dihydrofolate reductase interferes with DNA and protein synthesis. [ ]
Term info
Label
Dihydrofolate Reductase Inhibitor
Synonyms
- DHFR Inhibitor
- Dihydrofolate Reductase Inhibitor
Legacy Concept Name
Dihydrofolate_Reductase_Inhibitor
Preferred Name
Dihydrofolate Reductase Inhibitor
Semantic Type
Chemical Viewed Functionally
UMLS CUI
C2911817
code
C2153