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Sorafenib Tosylate

Go to external page http://purl.obolibrary.org/obo/NCIT_C2194

The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. [ ]

Term info

Label

Sorafenib Tosylate

Synonyms
  • 4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic Acid Methyamide-4-methylbenzenesulfonate Tosylate
  • BAY 43-9006 Tosylate
  • BAY 54-9085
  • Nexavar
  • SORAFENIB TOSYLATE
  • Sorafenib Tosylate
  • sorafenib
  • sorafenib tosylate
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Nexavar stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.

Accepted Therapeutic Use For

Advanced renal cell carcinoma; Metastatic Colorectal Cancer, Major Depressive Disorder

CAS Registry

475207-59-1

CHEBI ID

CHEBI:50928

Chemical Formula

C21H16ClF3N4O3.C7H8O3S

Display Name

Sorafenib Tosylate

FDA UNII Code

5T62Q3B36J

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C61948

Has Target

http://purl.obolibrary.org/obo/NCIT_C17476, http://purl.obolibrary.org/obo/NCIT_C26202, http://purl.obolibrary.org/obo/NCIT_C17328, http://purl.obolibrary.org/obo/NCIT_C26203, http://purl.obolibrary.org/obo/NCIT_C30164, http://purl.obolibrary.org/obo/NCIT_C17484, http://purl.obolibrary.org/obo/NCIT_C28496

Legacy Concept Name

BAY_43-9006

NSC Code

724772

Preferred Name

Sorafenib Tosylate

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C1676709

code

C2194