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Triapine

Go to external page http://purl.obolibrary.org/obo/NCIT_C2242

A synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro. (NCI04) [ ]

Term info

Label

Triapine

Synonyms
  • 3-AP
  • 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone
  • 3-Apct
  • 3-aminopyridine-2-carboxaldehyde thiosemicarbazone
  • OCX-191
  • Triapine
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A substance being studied in the treatment of cancer. It is a type of ribonucleotide reductase inhibitor.

CAS Registry

236392-56-6

Display Name

Triapine

Has Target

http://purl.obolibrary.org/obo/NCIT_C17101

NSC Code

663249

Preferred Name

Triapine

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0210403

code

C2242