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Recombinant Interferon Alfa

Go to external page http://purl.obolibrary.org/obo/NCIT_C225

A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04) [ ]

Term info

Label

Recombinant Interferon Alfa

Synonyms
  • Alferon
  • Alpha Interferon
  • Interferon Alfa
  • Leukocyte Interferon
  • Lymphoblast Interferon
  • Lymphoblastoid Interferon
  • Recombinant Interferon Alfa
  • alpha-Interferon
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

Accepted Therapeutic Use For

See specific agents.

Display Name

Recombinant Interferon Alfa

Legacy Concept Name

Therapeutic_Interferon_Alfa

Preferred Name

Recombinant Interferon Alfa

Semantic Type

Pharmacologic Substance, Amino Acid, Peptide, or Protein

UMLS CUI

C1622507

code

C225

Term relations

Related from:
Chemotherapy_Regimen_Has_Component