Geldanamycin Analogue
An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. [ ]
Term info
Geldanamycin Analogue
- Geldanamycin Analog
- Geldanamycin Analogue
- geldanamycin analog
An antineoplastic antibiotic drug that belongs to the family of drugs called ansamycins.
Geldanamycin_Analogue
255107, 210757, 255104
Geldanamycin Analogue
Antibiotic, Organic Chemical
C0796552
C2516
Term relations
- Ansamycin Antineoplastic Antibiotic
- Chemical_Or_Drug_Has_Physiologic_Effect some Signal Transduction Inhibition
- Chemical_Or_Drug_Affects_Gene_Product some Heat Shock Protein 90
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Chaperone Protein Inhibition
- Chemical_Or_Drug_Has_Physiologic_Effect some Protein Degradation Induction