Terminology Service for NFDI4Health
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Chromosomal Translocation Process

Go to external page http://purl.obolibrary.org/obo/NCIT_C25756

Any type of genetic recombination involving exchange of DNA between non-homologous chromosomes, which often occurs as the result of non-homologous end-joining of broken DNA strands. Chromosomal translocation is involved in repairing broken DNA and in maintaining cell viability at the expense of long term genomic stability. This process is is associated with particular types of leukemia, infertility and Down Syndrome. [ ]

Term info

Label

Chromosomal Translocation Process

Synonyms
  • Chromosomal Translocation Process
  • Translocation
  • translocation
ALT DEFINITION

A genetic change in which a piece of one chromosome breaks off and attaches to another chromosome. Sometimes pieces from two different chromosomes will trade places with each other. Translocations may lead to medical problems such as leukemia, breast cancer, schizophrenia, muscular dystrophy, and Down syndrome.

Legacy Concept Name

Translocation

Preferred Name

Chromosomal Translocation Process

Semantic Type

Phenomenon or Process

UMLS CUI

C1522702

code

C25756