Suppressor of Cytokine Signaling Family Gene
Suppressor of Cytokine Signaling (SOCS/SSI) Family Genes encode cytokine-specific-inducible negative feedback regulators that function downstream of cytokine receptors to attenuate signal transduction. Suppressor of Cytokine Signaling Proteins contain SH2 and SOCS BOX domains and are implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. SOCS proteins interact with multiple tyrosine kinase activated signaling proteins and inhibit cytokine signal transduction by binding to tyrosine kinase receptors. SOCS proteins regulate cell growth and survival, placental development, hematopoiesis, and T-cell allergic responses. (NCI) [ ]
Term info
Suppressor of Cytokine Signaling Family Gene
- CIS Family Gene
- Cytokine-Induced STAT Inhibitor Family Gene
- SOCS Family Gene
- SSI Family Gene
- STAT-Induced STAT Inhibitor Family Gene
- Suppressor of Cytokine Signaling Family Gene
Suppressor of Cytokine Signaling Family Protein
Suppressor_of_Cytokine_Signaling_Family_Gene
Suppressor of Cytokine Signaling Family Gene
Gene or Genome
C1336533
C25977
Term relations
- Signaling Pathway Gene
- Gene_Plays_Role_In_Process some Cytokine Signaling
- Gene_Found_In_Organism some Human