Terminology Service for NFDI4Health

Signal Transducer and Activator of Transcription Family Gene

Go to external page http://purl.obolibrary.org/obo/NCIT_C25991


Signal Transducer and Activator of Transcription Family Genes encode dual function cytoplasmic Signal Transducer and Activator of Transcription (STAT) proteins that are activated by tyrosine phosphorylation in response to a large number of cytokines, growth factors, and hormones. After activation they form homodimers or heterodimers that translocate to the nucleus where they either bind directly to regulatory DNA cis-elements of specific target genes or act together with other DNA-binding proteins in multiprotein transcription complexes to direct transcription. (NCI) [ ]

Term info

Label

Signal Transducer and Activator of Transcription Family Gene

Synonyms
  • STAT Family Gene
  • Signal Transducer and Activator of Transcription Family Gene
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

Display Name

Signal Transducer and Activator of Transcription Family Gene

Gene Encodes Product

Signal Transducer and Activator of Transcription

Legacy Concept Name

Signal_Transducer_and_Activator_of_Transcription_Family_Gene

Preferred Name

Signal Transducer and Activator of Transcription Family Gene

Semantic Type

Gene or Genome

UMLS CUI

C1335960

code

C25991