Terminology Service for NFDI4Health
Benzoylphenylurea
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http://purl.obolibrary.org/obo/NCIT_C2618
A low molecular weight agent with antineoplastic activity. Benzoylphenylurea binds to the colchicine binding site on tubulin, thereby blocking tubulin polymerization and disrupting mitotic function. This agent also inhibits DNA polymerase, and has been shown to arrest leukemia cells in the G1-S transition phase of the cell cycle. (NCI04) [ ]
Term info
Label
Benzoylphenylurea
Synonyms
- BPU
- Benzoylphenylurea
- benzoylphenylurea
Subsets
NCIT_C116978, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712
ALT DEFINITION
A substance being studied in the treatment of cancer. It is a type of antitubulin agent.
Contributing Source
CTRP
Display Name
Benzoylphenylurea
Has Target
http://purl.obolibrary.org/obo/NCIT_C17219, http://purl.obolibrary.org/obo/NCIT_C19172
Legacy Concept Name
Benzoylphenylurea
NSC Code
639829
PDQ Open Trial Search ID
38213
Preferred Name
Benzoylphenylurea
Semantic Type
Pharmacologic Substance, Organic Chemical
UMLS CUI
C0935907
code
C2618
Term relations
Subclass of:
- Colchicine-Site Binding Agent
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Microtubule Process
- Chemical_Or_Drug_Affects_Gene_Product some Tubulin
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of G1 to S Transition
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Enzyme Inhibition
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of Mitosis
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of Microtubule Polymerization
- Chemical_Or_Drug_Affects_Gene_Product some DNA Polymerase