Terminology Service for NFDI4Health
Integrator Complex Subunit 6
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http://purl.obolibrary.org/obo/NCIT_C26357
Integrator complex subunit 6 (887 aa, ~100 kDa) is encoded by the human INTS6 gene. This protein is involved in the synthesis of small nuclear RNA. [ ]
Term info
Label
Integrator Complex Subunit 6
Synonyms
- DBI-1
- DDX26
- DDX26 Protein
- DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26
- DEAD/H BOX 26
- DEAD/H Box Protein 26
- DICE1
- EGF Repeat Transmembrane Protein
- Int6
- Integrator Complex Subunit 6
- Protein DDX26
- Protein Deleted In Cancer 1
- RNA Helicase HDB
- RNA Helicase HDB/DICE1
DesignNote
Encoded by human DDX26 Gene (DEAD Family), the highly conserved candidate tumor suppressor 1687-amino acid 188.5-kD DEAD/H Box Protein 26 contains a vWF type A domain. With a likely important cellular function, DDX26 is expressed in a variety of fetal and adult tissues. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Legacy Concept Name
DEAD-H_Box_Protein-26
OMIM Number
604331
Preferred Name
Integrator Complex Subunit 6
Semantic Type
Amino Acid, Peptide, or Protein
Swiss Prot
Q9UL03
UMLS CUI
C0909050
code
C26357