Terminology Service for NFDI4Health

Caspase Gene

Go to external page http://purl.obolibrary.org/obo/NCIT_C26552


These genes encode caspases, a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the initial signaling events, as well as the downstream proteolytic cleavages, that result in apoptotic cell death. They are specific for aspartic acid at the P1 position and are divided into two classes based on the lengths of their N-terminal pro-domains. Caspases-1, -2, -4, -5, -8, and -10 have long pro-domains while caspases-3, -6, -7, and -9 have short pro-domains. (from Science 1998. 281:1312 and Br Med Bull 1997. 53:478) [ ]

Term info

Label

Caspase Gene

Synonyms
  • Caspase Gene
Legacy Concept Name

Caspase_Gene

Preferred Name

Caspase Gene

Semantic Type

Gene or Genome

UMLS CUI

C1332858

code

C26552