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Eribulin Mesylate

Go to external page http://purl.obolibrary.org/obo/NCIT_C26644

The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. [ ]

Term info

Label

Eribulin Mesylate

Synonyms
  • 2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one
  • B1939 Mesylate
  • E7389
  • ER-086526
  • ERIBULIN MESYLATE
  • Eribulin Mesylate
  • Halaven
  • Halichondrin B Analog
  • eribulin mesylate
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A drug used to treat metastatic breast cancer in patients who have already been treated with other chemotherapy. It is also being studied in the treatment of other types of cancer. Halaven may block cancer cell growth by stopping cell division. It belongs to the family of drugs called antitubulin agents.

Accepted Therapeutic Use For

unresectable or metastatic liposarcoma; breast cancer

CAS Registry

253128-41-5

Chemical Formula

C40H59NO11.CH4O3S

Display Name

Eribulin Mesylate

FDA UNII Code

AV9U0660CW

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C96748

Has Target

http://purl.obolibrary.org/obo/NCIT_C17219

NSC Code

707389

Preferred Name

Eribulin Mesylate

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C2608038

code

C26644