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Antisense Oligonucleotide GTI-2040

Go to external page http://purl.obolibrary.org/obo/NCIT_C26652

A 20-mer antisense oligonucleotide complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase. GTI-2040 decreases mRNA and protein levels of R2 in vitro and may inhibit tumor cell proliferation in human tumors in vivo. (NCI04) [ ]

Term info

Label

Antisense Oligonucleotide GTI-2040

Synonyms
  • Antisense Oligonucleotide GTI-2040
  • GTI-2040
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A substance being studied in the treatment of cancer. It blocks the production of a protein called ribonucleotide reductase, which helps cells make DNA. This may kill cancer cells that need ribonucleotide reductase to grow. It may also make cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of ribonucleotide reductase inhibitor.

CAS Registry

236391-66-5

Display Name

GTI-2040

Has Target

http://purl.obolibrary.org/obo/NCIT_C26621

NSC Code

722929

Preferred Name

Antisense Oligonucleotide GTI-2040

Semantic Type

Pharmacologic Substance, Nucleic Acid, Nucleoside, or Nucleotide

UMLS CUI

C1142995

code

C26652