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Sunitinib Malate

Go to external page http://purl.obolibrary.org/obo/NCIT_C26673

The orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells. [ ]

Term info

Label

Sunitinib Malate

Synonyms
  • Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
  • SU011248
  • SU11248
  • SUNITINIB MALATE
  • Sunitinib Malate
  • Sutent
  • sunitinib
  • sunitinib malate
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A drug used to treat gastrointestinal stromal tumors (GIST) that have not responded to treatment with imatinib mesylate (Gleevec). SU011248 is also used to treat advanced kidney cancer and is being studied in the treatment of other types of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor.

Accepted Therapeutic Use For

Gastrointestinal Stromal Tumor; Advanced Metastatic Renal Cell Carcinoma

CAS Registry

341031-54-7

Chemical Formula

C22H27FN4O2.C4H6O5

Display Name

Sunitinib Malate

FDA UNII Code

LVX8N1UT73

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C71622

Has Target

http://purl.obolibrary.org/obo/NCIT_C17322, http://purl.obolibrary.org/obo/NCIT_C17328, http://purl.obolibrary.org/obo/NCIT_C26202, http://purl.obolibrary.org/obo/NCIT_C26203, http://purl.obolibrary.org/obo/NCIT_C17975, http://purl.obolibrary.org/obo/NCIT_C18539, http://purl.obolibrary.org/obo/NCIT_C28496

NSC Code

736511

Preferred Name

Sunitinib Malate

Semantic Type

Pharmacologic Substance

UMLS CUI

C1700685

code

C26673