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Erlotinib Hydrochloride

Go to external page http://purl.obolibrary.org/obo/NCIT_C2693

The hydrochloride salt of a quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation. [ ]

Term info

Label

Erlotinib Hydrochloride

Synonyms
  • CP-358,774
  • Cp-358,774
  • ERLOTINIB HYDROCHLORIDE
  • Erlotinib Hydrochloride
  • N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride
  • OSI-774
  • Tarceva
  • erlotinib hydrochloride
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A drug used to treat certain types of non-small cell lung cancer. It is also used together with gemcitabine to treat pancreatic cancer and is being studied in the treatment of other types of cancer. Erlotinib hydrochloride is a type of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.

Accepted Therapeutic Use For

Malignant glioma; Locally advanced or metastic non-small cell lung carcinoma; Locally advanced, unresectable or metastatic pancreatic carcinoma

CAS Registry

183319-69-9

CHEBI ID

CHEBI:53509

Chemical Formula

C22H23N3O4.HCl

Display Name

Erlotinib Hydrochloride

FDA UNII Code

DA87705X9K

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C65530

Has Target

http://purl.obolibrary.org/obo/NCIT_C17068

NSC Code

718781

Preferred Name

Erlotinib Hydrochloride

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C1533491

code

C2693