Vincristine Sulfate Liposome
A sphingomyelin/cholesterol liposomal formulation of vincristine sulfate with potential antineoplastic activity. Vincristine, a vinca alkaloid isolated from the plant Vinca rosea, irreversibly binds to and stabilizes tubulin, thereby interrupting microtubule assembly/disassembly dynamics, thereby preventing the formation of the mitotic spindle and leading to cell cycle arrest in metaphase. Liposomal encapsulation prolongs bioavailability of vincristine, increases its delivery to tumor tissues and reduces its toxicity profile. Compared to standard liposomal delivery, sphingosomal drug delivery further increases circulation time of serum drug and enhances drug accumulation at tumor sites, thereby leading to a further increase in efficacy. [ ]
Term info
Vincristine Sulfate Liposome
- Marqibo
- Vincristine Sulfate Liposome
NCIT_C116978, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712
acute lymphoblastic leukemia (ALL)
CTRP
Vincristine Sulfate Liposome
http://purl.obolibrary.org/obo/NCIT_C17219
Vincristine_Sulfate_Liposomes
38100
Vincristine Sulfate Liposome
Pharmacologic Substance, Organic Chemical
C0935690
C2702