B-Cell Differentiation
In mammalian bone marrow, B-Cell Development consists of progressive differentiation from CD34+ progenitor cells to plasma and memory B cells by positive/negative selection in response to local signals, including antigens and cytokines. B cell development begins with immunoglobulin gene somatic recombination and pre-B cell receptor expression. Antigen-induced signal transduction via BCR-associated ITAM molecules activates B cell proliferation. Further differentiation involves additional immunoglobulin gene recombination and expression. Antigen-stimulated circulating (resting) B cells proliferate and differentiate into plasma and memory B cell clones expressing immunoglobulins with the same antigen recognition site. [ ]
Term info
B-Cell Differentiation
- B Cell Differentiation
- B Lymphocyte Differentiation
- B-Cell Development
- B-Cell Differentiation
B-Cell_Development
B-Cell Differentiation
Phenomenon or Process
C1511002
C28391
Term relations
- Cell Differentiation Process
- Biological_Process_Is_Part_Of_Process some Immune System Process
- Biological_Process_Has_Result_Anatomy some B-Lymphocyte
- Biological_Process_Is_Part_Of_Process some Immune Response Process
- Biological_Process_Is_Part_Of_Process some Host Defense Mechanism