Terminology Service for NFDI4Health

M-Phase Promoting Factor

Go to external page http://purl.obolibrary.org/obo/NCIT_C28557


M Phase-Promoting Factor is a protein kinase complex that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2. [ ]

Term info

Label

M-Phase Promoting Factor

Synonyms
  • M Phase-Promoting Factor
  • M-Phase Promoting Factor
  • M-Phase-Promoting Factor
  • MPF
  • Maturation Promoting Factor
  • Maturation-Promoting Factor
  • Mitosis Promoting Factor
  • Mitosis-Promoting Factor
DesignNote

M-phase promoting factor is a heterodimer of the serine/threonine protein kinase cyclin-dependent kinase 1 with cyclin b.

Legacy Concept Name

M-Phase_Promoting_Factor

Preferred Name

M-Phase Promoting Factor

Semantic Type

Amino Acid, Peptide, or Protein, Enzyme

UMLS CUI

C0079805

code

C28557