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Imexon

Go to external page http://purl.obolibrary.org/obo/NCIT_C29115

A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. (NCI04) [ ]

Term info

Label

Imexon

Synonyms
  • 4-imino-1,3-diazabicyclo[3,1,0]-hexan-2-one
  • Amplimexon
  • IMEXON
  • Imexon
  • imexon
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A substance that is being studied in the treatment of some types of cancer, including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma. It belongs to the family of drugs called cyanoaziridine derivatives.

CAS Registry

59643-91-3

Display Name

Imexon

FDA UNII Code

8F63U28T2V

NSC Code

714597

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0097147

code

C29115