Terminology Service for NFDI4Health
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Dr1-Associated Corepressor

Go to external page http://purl.obolibrary.org/obo/NCIT_C29572

Dr1-associated corepressor (205 aa, ~22 kDa) is encoded by the human DRAP1 gene. This protein is involved in the repression of gene expression. [ ]

Term info

Label

Dr1-Associated Corepressor

Synonyms
  • DR1-Associated Protein 1
  • Dr1-Associated Corepressor
  • NC2-Alpha
  • Negative Cofactor 2 Alpha
DesignNote

DR1 interacts with the TATA-binding protein (TBP) of TFIID and prevents formation of an active transcription complex by precluding TFIIA and/or TFIIB entry into the preinitiation complex. DRAP1 and DR1 interaction is required for corepressor function and stabilizes the TBP-DR1-DNA complex. DRAP1 protein contains a histone fold motif at the N terminus and a proline-rich region at the C terminus. The binding of DRAP1 to DR1 is dependent on the histone fold motif present in each protein. DRAP1 expression facilitates the maintenance of a differentiated state by silencing specific genes.

Legacy Concept Name

DR1-Associated_Protein-1

OMIM Number

602289

Preferred Name

Dr1-Associated Corepressor

Semantic Type

Amino Acid, Peptide, or Protein, Biologically Active Substance

Swiss Prot

Q14919

UMLS CUI

C0388904

code

C29572