Terminology Service for NFDI4Health
JSON

Protein Phosphatase 2A Regulatory Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C34083

A subunit of protein phosphatase 2A that serves as a scaffold for the formation and localization of the holoenzyme complex and plays a role in the modulation of substrate specificity. [ ]

Term info

Label

Protein Phosphatase 2A Regulatory Protein

Synonyms
  • Protein Phosphatase 2A Regulatory Protein
  • Protein Phosphatase 2A Regulatory Protein Subunit
DesignNote

A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression.

Legacy Concept Name

Protein_Phosphatase_Regulatory_Protein

Preferred Name

Protein Phosphatase 2A Regulatory Protein

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C1335548

code

C34083