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ZBTB16-RARA Fusion Protein Expression

Go to external page http://purl.obolibrary.org/obo/NCIT_C37220

A fusion protein encoded by a t(15;17) translocation, which involves the human genes ZBTB16 and RARA and is characteristic of acute promyelocytic leukemia. It is a transcriptional repressor with both gain-of-function and dominant-negative properties, resulting in transcriptional repression of retinoic acid and non-retinoic acid target genes and culminating in differentiation arrest. [ ]

Term info

Label

ZBTB16-RARA Fusion Protein Expression

Synonyms
  • PLZF-RARalpha Fusion Protein Expression
  • PLZF/RARA Fusion Protein Expression
  • ZBTB16-RARA Fusion Protein Expression
  • ZBTB16/RARA Fusion Protein Expression
Legacy Concept Name

PLZF-RARalpha_Fusion_Protein_Expression

Preferred Name

ZBTB16-RARA Fusion Protein Expression

Semantic Type

Cell or Molecular Dysfunction

UMLS CUI

C1518796

code

C37220