Terminology Service for NFDI4Health
JSON

Ixabepilone

Go to external page http://purl.obolibrary.org/obo/NCIT_C37452

An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. [ ]

Term info

Label

Ixabepilone

Synonyms
  • (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
  • Azaepothilone B
  • BMS 247550
  • BMS-247550
  • BMS247550
  • Epothilone
  • Epothilone-B BMS 247550
  • IXABEPILONE
  • Ixabepilone
  • Ixempra
  • ixabepilone
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A drug used to treat metastatic or locally advanced breast cancer that has not improved after treatment with certain other anticancer drugs. It is also being studied in the treatment of other types of cancer. Ixempra stops the growth of tumor cells by blocking cell division. It is a type of epothilone analog.

Accepted Therapeutic Use For

metastatic or locally advanced breast cancer.

CAS Registry

219989-84-1

CHEBI ID

CHEBI:63605

Chemical Formula

C27H42N2O5S

Display Name

Ixabepilone

FDA UNII Code

K27005NP0A

Has Target

http://purl.obolibrary.org/obo/NCIT_C17219

Legacy Concept Name

Ixabepilone

NSC Code

710428

Preferred Name

Ixabepilone

Semantic Type

Pharmacologic Substance

UMLS CUI

C1135132

code

C37452