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Tanespimycin

Go to external page http://purl.obolibrary.org/obo/NCIT_C37899

A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. [ ]

Term info

Label

Tanespimycin

Synonyms
  • 17-(Allylamino)-17-demethoxygeldanamycin
  • 17-AAG
  • 17-Allylamino-17-demethoxygeldanamycin
  • 17-Demethoxy-17-(2-propenylamino)geldanamycin
  • 17-N-allylamino-17-demethoxy geldanamycin
  • 17-N-allylamino-17-demethoxygeldanamycin
  • Geldanamycin, 17-allylamino-17-demethoxy-
  • KOS-953
  • TANESPIMYCIN
  • Tanespimycin
  • tanespimycin
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A substance being studied in the treatment of cancer. It is made from an antibiotic called geldanamycin. Tanespimycin helps cause the breakdown of certain proteins in the cell, and may kill cancer cells. It is a type of antineoplastic antibiotic and a type of HSP90 inhibitor.

Accepted Therapeutic Use For

Chronic Myelogenous Leukemia

CAS Registry

75747-14-7

CHEBI ID

CHEBI:64153

Chemical Formula

C31H43N3O8

Display Name

Tanespimycin

FDA UNII Code

4GY0AVT3L4

Has Target

http://purl.obolibrary.org/obo/NCIT_C17766

Legacy Concept Name

_17-Allylamino_17-demethoxygeldanamycin

NSC Code

330507

Preferred Name

Tanespimycin

Semantic Type

Antibiotic, Organic Chemical

UMLS CUI

C0675974

code

C37899