Betulinic Acid
A pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Although originally thought to exhibit specific cytotoxicity against melanoma cells, this agent has been found to be cytotoxic against non-melanoma tumor cell types including neuroectodermal and brain tumor cells. [ ]
Term info
Betulinic Acid
- (3beta)-3-Hydroxy-lup-20(29)-en-28-oic Acid
- ALS-357
- BETULINIC ACID
- Betulinic Acid
- Mairin
NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712
472-15-1
C30H48O3
CTRP, FDA
Betulinic Acid
4G6A18707N
Betulinic_Acid
113090
496932
496932
Betulinic Acid
Pharmacologic Substance, Organic Chemical
C0053530
C38126
Term relations
- Immunostimulant
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Unknown Cellular or Molecular Mechanism
- Chemical_Or_Drug_Has_Physiologic_Effect some Positive Regulation of Apoptosis
- Chemical_Or_Drug_Has_Physiologic_Effect some Positive Regulation of Cell Differentiation
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of Cell Cycle